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1

Protein engineering

Leatherbarrow, Robin J., Fersht, Alan R.

Journal:

Protein Engineering Design and Selection

Year:

1986

Language:

english

File:

PDF, 1.01 MB

english, 1986

2

Second-Order Kinetic Analysis of IAsys Biosensor Data: Its Use and Applicability

Paul R. Edwards, Colin H. Maule, Robin J. Leatherbarrow, Donald J. Winzor

Journal:

Analytical Biochemistry

Year:

1998

Language:

english

File:

PDF, 233 KB

english, 1998

3

Designer catalytic antibodies

Leatherbarrow, Robin J.

Journal:

Year:

1989

File:

PDF, 279 KB

1989

4

Using linear and non-linear regression to fit biochemical data

Leatherbarrow, Robin J.

Journal:

Trends in Biochemical Sciences

Year:

1990

Language:

english

File:

PDF, 486 KB

english, 1990

5

Enantioselective synthesis of (+)-aspercyclide A

Sejberg, Jimmy J.P., Smith, Lucy D., Leatherbarrow, Robin J., Beavil, Andrew J., Spivey, Alan C.

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 620 KB

english, 2013

6

Identification of chymotrypsin inhibitors from a second-generation template assisted combinatorial peptide library

Jeffrey D. Mcbride, Hamzah N. Freeman, Robin J. Leatherbarrow

Journal:

Journal of Peptide Science

Year:

2000

Language:

english

File:

PDF, 87 KB

english, 2000

7

Peptide mimics of the Bowman–Birk inhibitor reactive site loop

Jeffrey D. McBride, Emma M. Watson, Arnd B. E. Brauer, Agnès M. Jaulent, Robin J. Leatherbarrow

Journal:

Year:

2002

Language:

english

File:

PDF, 540 KB

english, 2002

8

Immobilized Protease-Assisted Synthesis of Engineered Cysteine-Knot Microproteins

Panumart Thongyoo, Agnes M. Jaulent, Edward W. Tate, Robin J. Leatherbarrow

Journal:

Year:

2007

Language:

english

File:

PDF, 201 KB

english, 2007

9

Analysis of Protein–Protein Interactions by Using Droplet-Based Microfluidics

Monpichar Srisa-Art, Dong-Ku Kang, Jongin Hong, Hyun Park, Robin J. Leatherbarrow, Joshua B. Edel, Soo-Ik Chang, Andrew J. deMello

Journal:

Year:

2009

Language:

english

File:

PDF, 519 KB

english, 2009

10

Cover Picture: Analysis of Protein–Protein Interactions by Using Droplet-Based Microfluidics (ChemBioChem 10/2009)

Monpichar Srisa-Art, Dong-Ku Kang, Jongin Hong, Hyun Park, Robin J. Leatherbarrow, Joshua B. Edel, Soo-Ik Chang, Andrew J. deMello

Journal:

Year:

2009

Language:

english

File:

PDF, 771 KB

english, 2009

11

Reagent-Controlled Stereoselective Synthesis of Lignan-Related Tetrahydrofurans.

Steven M. Miles, Stephen P. Marsden, Robin J. Leatherbarrow, William J. Coates

Journal:

Year:

2005

File:

PDF, 39 KB

2005

12

A Novel, Stereoselective and Convergent Synthesis of Aryltetralins.

Steven M. Miles, Stephen P. Marsden, Robin J. Leatherbarrow, William J. Coates

Journal:

Year:

2005

File:

PDF, 19 KB

2005

13

ChemInform Abstract: Total Synthesis of (.+-.)-Aspercyclide A and Its C19 Methyl Ether.

James L. Carr, Daniel A. Offermann, Mary D. Holdom, Philip Dusart, Andrew J. P. White, Andrew J. Beavil, Robin J. Leatherbarrow, Stephen D. Lindell, Brian J. Sutton, Alan C. Spivey

Journal:

Year:

2010

File:

PDF, 31 KB

2010

14

N-Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

Paul W. Bowyer, Edward W. Tate, Robin J. Leatherbarrow, Anthony A. Holder, Deborah F. Smith, Katherine A. Brown

Journal:

Year:

2008

Language:

english

File:

PDF, 396 KB

english, 2008

15

Carbon-13 nuclear magnetic resonance relaxation study of chymotrypsin inhibitor 2 (CI-2)

Robin J. Leatherbarrow, Stephen J. Matthews

Journal:

Magnetic Resonance in Chemistry

Year:

1992

Language:

english

File:

PDF, 555 KB

english, 1992

16

Determination of Association Rate Constants by an Optical Biosensor Using Initial Rate Analysis

Paul R. Edwards, Robin J. Leatherbarrow

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 126 KB

english, 1997

17

Use of nonlinear regression to analyze enzyme kinetic data: Application to situations of substrate contamination and background subtraction

Robin J. Leatherbarrow

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 460 KB

english, 1990

18

Imaging of proteins by scanning tunnelling microscopy

Timothy N.C. Wells, Margaret Stedman, Robin J. Leatherbarrow

Journal:

Ultramicroscopy

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

19

Inhibition of human β-tryptase by Bowman–Birk inhibitor derived peptides: creation of a new tri-functional inhibitor

Dina Scarpi, Jeffrey D. McBride, Robin J. Leatherbarrow

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 421 KB

english, 2004

20

A continuous assay for foot-and-mouth disease virus 3C protease activity

Agnès M. Jaulent, Aodhnait S. Fahy, Stephen R. Knox, James R. Birtley, Núria Roqué-Rosell, Stephen Curry, Robin J. Leatherbarrow

Journal:

Analytical Biochemistry

Year:

2007

Language:

english

File:

PDF, 220 KB

english, 2007

21

Resisting degradation by human elastase: Commonality of design features shared by ‘canonical’ plant and bacterial macrocyclic protease inhibitor scaffolds

Arnd B.E. Brauer, Jeffrey D. McBride, Geoff Kelly, Stephen J. Matthews, Robin J. Leatherbarrow

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 669 KB

english, 2007

22

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis

Dina Scarpi, Ernesto G Occhiato, Andrea Trabocchi, Robin J Leatherbarrow, Arnd B.E Brauer, Marco Nievo, Antonio Guarna

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 587 KB

english, 2001

23

Analysis of molecular recognition using optical biosensors

Robin J Leatherbarrow, Paul R Edwards

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 69 KB

english, 1999

24

Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library

Jeffrey D. McBride, Hamzah N. M. Freeman, Robin J. Leatherbarrow

Journal:

Year:

1999

Language:

english

File:

PDF, 421 KB

english, 1999

25

Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library

Edward W. Tate, Paul W. Bowyer, Katherine A. Brown, Deborah F. Smith, Anthony A. Holder, Robin J. Leatherbarrow

Journal:

Signal Transduction

Year:

2006

Language:

english

File:

PDF, 539 KB

english, 2006

26

The use of osmolytes to facilitate protein NMR spectroscopy

Stephen J. Matthews, Robin J. Leatherbarrow

Journal:

Journal of Biomolecular NMR

Year:

1993

Language:

english

File:

PDF, 201 KB

english, 1993

27

Solution Structure of a Novel C2-Symmetrical Bifunctional Bicyclic Inhibitor Based on SFTI-1

Agnès M. Jaulent, Arnd B. E. Brauer, Stephen J. Matthews, Robin J. Leatherbarrow

Journal:

Journal of Biomolecular NMR

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

28

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors

Natasha A. Karp, Paul R. Edwards, Robin J. Leatherbarrow

Journal:

Biosensors and Bioelectronics

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

29

Stability of protease inhibitors based on the Bowman-Birk reactive site loop to hydrolysis by proteases

TALAL GARIANI, ROBIN J. LEATHERBARROW

Journal:

Chemical Biology & Drug Design

Year:

1997

Language:

english

File:

PDF, 801 KB

english, 1997

30

Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships

Fersht, Alan R., Leatherbarrow, Robin J., Wells, Tim N. C.

Journal:

Year:

1986

File:

PDF, 296 KB

1986

31

On to the second generation

Leatherbarrow, Robin J.

Journal:

Year:

1990

File:

PDF, 143 KB

1990

32

Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein–protein interfaces

Bradshaw, Richard T., Aronica, Pietro G. A., Tate, Edward W., Leatherbarrow, Robin J., Gould, Ian R.

Journal:

Chemical Science

Year:

2012

Language:

english

File:

PDF, 469 KB

english, 2012

33

A fluorescence-based assay for N-myristoyltransferase activity

Victor Goncalves, James A. Brannigan, Emmanuelle Thinon, Tayo O. Olaleye, Remigiusz Serwa, Salvatore Lanzarone, Anthony J. Wilkinson, Edward W. Tate, Robin J. Leatherbarrow

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 309 KB

english, 2012

34

A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue

Zulfiqar Hasan, Robin J Leatherbarrow

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1998

Language:

english

File:

PDF, 115 KB

english, 1998

35

The role of the P2′ position of Bowman-Birk proteinase inhibitor in the inhibition of trypsin: Studies on P2′ variation in cyclic peptides encompassing the reactive site loop

Talal Gariani, Jeffrey D McBride, Robin J Leatherbarrow

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 167 KB

english, 1999

36

Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors

GONZALO J. DOMINGO, ROBIN J. LEATHERBARROW, NEIL FREEMAN, SHILA PATEL, MALCOLM WEIR

Journal:

Chemical Biology & Drug Design

Year:

1995

Language:

english

File:

PDF, 902 KB

english, 1995

37

Selection of Chymotrypsin Inhibitors from a Conformationally-constrained Combinatorial Peptide Library

Jeffrey D. McBride, Neil Freeman, Gonzalo J. Domingo, Robin J. Leatherbarrow

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 556 KB

english, 1996

38

The role of threonine in the P2 position of bowman-birk proteinase inhibitors: studies on P2 variation in cyclic peptides encompassing the reactive site loop

Jeffrey D. McBride, Arnd B.E. Brauer, Marco Nievo, Robin J. Leatherbarrow

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 610 KB

english, 1998

39

The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural β-hairpin motif

Arnd B.E. Brauer, Geoff Kelly, Jeffrey D. McBride, Robert M. Cooke, Stephen J. Matthews, Robin J. Leatherbarrow

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 332 KB

english, 2001

40

The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural β-hairpin motif

Arnd B.E. Brauer, Geoff Kelly, Jeffrey D. McBride, Robert M. Cooke, Stephen J. Matthews, Robin J. Leatherbarrow

Journal:

Journal of Molecular Biology

Year:

2001

File:

PDF, 131 KB

2001

41

The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A

Robin J. Leatherbarrow, Raymond A. Dwek

Journal:

Year:

1983

Language:

english

File:

PDF, 355 KB

english, 1983

42

Structure of immunoglobulin G by scanning tunnelling microscopy

Robin J. Leatherbarrow, Margaret Stedman, Timothy N.C. Wells

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 369 KB

english, 1991

43

Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target

Stephen Curry, Núria Roqué-Rosell, Patricia A. Zunszain, Robin J. Leatherbarrow

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2007

Language:

english

File:

PDF, 436 KB

english, 2007

44

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

Patricia A. Zunszain, Stephen R. Knox, Trevor R. Sweeney, Jingjie Yang, Núria Roqué-Rosell, Graham J. Belsham, Robin J. Leatherbarrow, Stephen Curry

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.46 MB

english, 2010

45

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

James A. Brannigan, Barbara A. Smith, Zhiyong Yu, Andrzej M. Brzozowski, Michael R. Hodgkinson, Asher Maroof, Helen P. Price, Franziska Meier, Robin J. Leatherbarrow, Edward W. Tate, Deborah F. Smith,

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 4.65 MB

english, 2010

46

The conserved P1′ Ser of Bowman–Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop

Arnd B.E. Brauer, Robin J. Leatherbarrow

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

47

Effector functions of a monoclonal aglycosylated mouse IgG2a: Binding and activation of complement component C1 and interaction with human monocyte Fc receptor

Robin J. Leatherbarrow, Thomas W. Rademacher, Raymond A. Dwek, Jennifer M. Woof, Anthony Clark, Dennis R. Burton, Neil Richardson, Arnold Feinstein

Journal:

Molecular Immunology

Year:

1985

Language:

english

File:

PDF, 1.02 MB

english, 1985

48

Diversification of the IgG molecule by oligosaccharides

Pauline M. Rudd, Robin J. Leatherbarrow, Thomas W. Rademacher, Raymond A. Dwek

Journal:

Molecular Immunology

Year:

1991

Language:

english

File:

PDF, 902 KB

english, 1991

49

N-Myristoyl transferase-mediated protein labelling in vivo

Heal, William P., Wickramasinghe, Sasala R., Leatherbarrow, Robin J., Tate, Edward W.

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 580 KB

english, 2008

50

Binding of complement subcomponent Clq to mouse IgGl, IgG2a AND IgG2b: A novel Clq binding assay

Robin J. Leatherbarrow, Raymond A. Dwek

Journal:

Molecular Immunology

Year:

1984

Language:

english

File:

PDF, 778 KB

english, 1984